Effect of entacapone, a COMT inhibitor,
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V. V. Myllylä; K. A. Sotaniemi; A. Illi; K. Suominen; T. Keränen
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Article
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1993
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Springer
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English
⚖ 563 KB
In an open, randomised, cross-over study we investigated the effect of a single 200 mg oral dose of entacapone, a novel catechol-O-methyltransferase (COMT) inhibitor, on the pharmacokinetics and metabolism of levodopa/carbidopa, and on the cardiovascular responses (blood pressure and pulse rate vari