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Behavioural and immunological effects of the antihistamine terfenadine in olfactory bulbectomized rats

โœ Scribed by Cai Song; Bernadette Earley; B.E. Leonard

Book ID
119175819
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
581 KB
Volume
6
Category
Article
ISSN
0924-977X

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โœ CAI SONG; B. E. LEONARD ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 102 KB ๐Ÿ‘ 2 views

The olfactory bulbectomized (OB) rat has been developed as an animal model of depression. In the novel `open ยฎeld' environment, OB rats showed a hyperactivity which was attenuated by chronic treatment with desipramine (7 . 5 mg/ kg) for 20 days. Neutrophil phagocytosis was suppressed by the lesion,