Behaviour of some lysosomal enzymes in the plasma of insulin dependent diabetic patients during artificial pancreas treatment
✍ Scribed by A.B. Burlina; G. Goi; A. Fabi; A. Lombardo; D. Gaburro; G. Tettamanti
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 598 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0009-9120
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✦ Synopsis
The plasma levels of three lysosomal enzymes, p-o-N-acetylglucosaminidase, f&o-glucuronidase, and a-L-fucosidase, were fluorimetrically determined in seven insulin-dependent diabetic patients one day before, one day after, and during a two-day treatment with the artiffcial pancreas, at 4 to 5 h intervals. A statistically significant decrease of the plasma level of each enzyme was observed during artificial pancreas treatment. The extent of decrease was 30 to 35% for p-N-acetylglucosaminidase, 35 to 40% for g-o-glucuronidase, and 20 to 25% for a-L-fucosidase. The decrease occurred earlier (at the first day of treatment) for f3-o-N-acetyfgfucosaminidase, and later (at the second day of treatment, and lasttng to the first day after treatment) for the other two enzymes. These results suggest a direct connection between the lysosomal apparatus and insulin-controlled metabolic pathways, and a potential role for lysosomal enzymes as indicators of the metabolic compensation in diabetes.