Behavioral Testing of Antidepressant Compounds: An Analysis of Crossover Design for Correlated Binary Data
✍ Scribed by Ziv Shkedy; Veerle Vandersmissen; Geert Molenberghs; Hansfried Van Craenendonck; Nancy Aerts; Thomas Steckler; Luc Bijnens
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 139 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0323-3847
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✦ Synopsis
The differential reinforcement of low-rate 72 seconds schedule (DRL-72) is a standard behavioral test procedure for screening potential antidepressant compounds. The protocol for the DRL-72 experiment, proposed by , consists of using a crossover design for the experiment and one-way ANOVA for the statistical analysis. In this paper we discuss the choice of several crossover designs for the DRL-72 experiment and propose to estimate the treatment effects using either generalized linear mixed models (GLMM) or generalized estimating equation (GEE) models for clustered binary data.