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Behavioral profile of amisulpride in agonistic encounters between male mice

✍ Scribed by Juan Manuel Manzaneque; José Francisco Navarro

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
29 KB
Volume
25
Category
Article
ISSN
0096-140X

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✦ Synopsis

Amisulpride is a substituted benzamide derivative that acts as a selective dopamine D2/ D3 receptor antagonist. Although the anti-aggressive properties of neuroleptic drugs are well known, the effects of amisulpride on agonistic interactions have not been explored, and there are no studies comparing acute and subchronic effects of this compound on aggression in rodents. In this study, we examined the action of amisulpride (5-25 mg/kg, i.p), administered acutely or subchronically for 10 days, on agonistic behavior elicited by isolation in male mice. Individually housed mice were exposed to anosmic "standard opponents" 30 min after drug administration, and the encounters were videotaped and evaluated using an ethologically based analysis. After acute treatment, amisulpride (5-20 mg/kg) exhibited an ethopharmacological profile characterized by a marked decrease of offensive behaviors (threat and attack) without an impairment of motor activity. By contrast, the anti-aggressive action of the highest dose used (25 mg/ kg) was accompanied by a weak increase of immobility. Body care was also significantly enhanced after treatment with the drug (20 and 25 mg/kg), emphasizing the involvement of dopaminergic receptors in this behavior. After subchronic treatment, no tolerance to amisulpride anti-aggressive activity was observed. Overall, this behavioral profile is similar to that observed by other atypical neuroleptics. Aggr. Behav. 25:225-232, 1999.

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