Behavioral effects of short-term administration of lithium and valproic acid in rats
โ Scribed by Hilarie C. Tomasiewicz; Stephen D. Mague; Bruce M. Cohen; William A. Carlezon Jr.
- Book ID
- 113501659
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 621 KB
- Volume
- 1093
- Category
- Article
- ISSN
- 0006-8993
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Pregnant Sprague-Dawley rats were treated with 0, 150 or 200 mg/kg valproic acid by gavage (VPA) on days 7-18 of gestation. These doses produced no maternal toxicity, reproductive effects or effects on offspring growth and survival. Maternal plasma VPA peak levels averaged 99 and 134 micrograms/ml 1
Functional, biochemical and histological parameters of hepatotoxicity were assessed in male Sprague-Dawley rats receiving amiodarone (Am) short-term by gavage (5, 50, 150 and 500 mg Am kg-' day-', 10 days) or dietary exposure (50 ppm, 1500 ppm, 4-week duration), or by long-term dietary exposure (50