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Behavioral Changes and [123I]IBZM Equilibrium SPECT Measurement of Amphetamine-Induced Dopamine Release in Rhesus Monkeys Exposed to Subchronic Amphetamine

✍ Scribed by Stacy A Castner; Mohammed S Al-Tikriti; Ronald M Baldwin; John P Seibyl; Robert B Innis; Patricia S Goldman-Rakic

Book ID: 114282405
Publisher: Nature Publishing Group
Year: 2000
Tongue: English
Weight: 287 KB
Volume: 22
Category: Article
ISSN: 1470-634X
DOI: 10.1016/s0893-133x(99)00080-9

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Binding competition between endogenous dopamine (DA) and the D 2 receptor radiotracer [ 123 I]IBZM allows measurement of the change in synaptic DA following amphetamine challenge with SPECT in the living human brain. Previous investigations using this technique in healthy subjects have shown that th