✦ LIBER ✦

Behavioral and physiological studies of a convulsing mutant chicken (Gallus domesticus)

✍ Scribed by Kuenzel, Wayne J. ;Rubenstein, James B.

Publisher: John Wiley and Sons
Year: 1974
Tongue: English
Weight: 627 KB
Volume: 187
Category: Article
ISSN: 0022-104X
DOI: 10.1002/jez.1401870108

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Female chicks carrying a recessive lethal, sex‐linked gene designated px (paroxysm) develop seizures. In a population of px chicks (hemizygous females), the mean age of showing the first seizure is 19 days. The seizure syndrome can be generally divided into four phases: (1) alert phase (vocalization and/or running), (2) clonic phase (wing flapping, legs flex), (3) tonic phase (opisthotonos), and, (4) recovery phase. Seizures are spontaneous and recurrent but can also be precipitated by various environmental stimuli or by electrical stimulation of brain. Electroencephalogram recordings during seizures consistently show repetitive high amplitude spikes. Dilantin and sodium pentobarbital were effective in inhibiting electrically induced convulsions. No gross brain lesions were detected with light microscopy.

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