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Behavioral and biochemical investigations of bupropion metabolites

✍ Scribed by Mikhail L Bondarev; Tatiana S Bondareva; Richard Young; Richard A Glennon

Book ID
114015805
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
404 KB
Volume
474
Category
Article
ISSN
0014-2999

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Biochemical, neurophysiological, and behavioral effects of Wy-45,233 and other identified metabolites of the antidepressant venlafaxine
✍ Dr. Eric A. Muth; John A. Moyer; J. Thomas Haskins; Terrance H. Andree; G. E. Mo πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 514 KB

Seven metabolites of venlafaxine, identified in several species, were examined for CNS pharmacological activity in rodents. The 0-desmethyl compound Wy-45,233, which is the major metabolite in man, had the greatest preclinical activity. This metabolite exhibited an antidepressant profile (monoamine