Behavioral Alterations in Rats Prenatally Exposed to Valproic Acid: Animal Model of Autism
✍ Scribed by Schneider, Tomasz; Przewłocki, Ryszard
- Book ID
- 111677210
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 149 KB
- Volume
- 30
- Category
- Article
- ISSN
- 1470-634X
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Pregnant Sprague-Dawley rats were treated with 0, 150 or 200 mg/kg valproic acid by gavage (VPA) on days 7-18 of gestation. These doses produced no maternal toxicity, reproductive effects or effects on offspring growth and survival. Maternal plasma VPA peak levels averaged 99 and 134 micrograms/ml 1
## Abstract Sexually dimorphic patterns of cortical lateralization are documented extensively in both human and animal brains. Male rats tend to exhibit pronounced right hemisphere dominance compared with females, whereas females typically exhibit more diffuse lateralization patterns and greater le
Sex-specific patterns of cerebral cortical lateralization have been documented consistently in both the human and animal brain. Male rats tend to exhibit pronounced right hemisphere dominance compared with females, while females typically exhibit more diffuse lateralization patterns and greater left