Behavior of specific natural lecithins and cholesterol at the air water-interface

✍ Scribed by Dolly Ghosh; Richard L. Lyman; J. Tinoco

• Publisher: Elsevier Science
• Year: 1971
• Tongue: English
• Weight: 460 KB
• Volume: 7
• Category: Article
• ISSN: 0009-3084
• DOI: 10.1016/0009-3084(71)90030-2

✦ Synopsis

Individual molecular species of lecithins were mixed with cholesterol and their pressurearea curves were measured at the air-water interface at 22 _~ 1". The lecithins investigated were*: L-16:0-16:0-, D-16:0-16:0-, L-16:0-18:3-, L-18:0-18:3-, L-16:0-20:4-, L-18:0-20:4-and L-18:0-18:0-1ecithins. All of these except the D-16:0-16:0-and L-18:0-18:0lecithins have been found in nature. Considerable condensation of monolayers with cholesterol was observed in all cases except that of 18:0-18:0-lecithin, in which there was little condensation. The naturally-occurring structure of lecithins, that is, 1-saturated-2-unsaturated, leads to large condensations in mixed monolayers. This geometrical fit between cholesterol and lecithins may be of importance in enzyme reactions involving cholesterol or lecithins. * Abbreviations: Fatty acids -number of carbon atoms: number of double bonds; Lecithins -substituent in position 1 named first, substituent in position 2 named second. For example, 16: 0-18 : 3-lecithin --1-palmitoyl-2-1inolenoyl lecithin.