๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Behavior of acylated 1-hydroxybenzotriazole

โœ Scribed by Kusuo Horiki

Book ID
104235932
Publisher
Elsevier Science
Year
1977
Tongue
French
Weight
246 KB
Volume
18
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

โœฆ Synopsis

K6nig and Geiger' established that 1-hydroxybenzotriazole(HOBt) is an efficient catalyst of peptide bond formation with either dicyclohexylcarbodiimide or the active ester method. They also observed that some active HOBt esters of N-protected amino acids, except that of threonine, exist in the N-acyl form (2~) in the crystalline state in contrast to the 0-acyl form (&) in dioxane.

๐Ÿ“œ SIMILAR VOLUMES

Neutral hydrolysis reaction of acetyl 1-
Neutral hydrolysis reaction of acetyl 1-hydroxybenzotriazole
โœ Kusuo Horiki ๐Ÿ“‚ Article ๐Ÿ“… 1977 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 237 KB

The very recent report of the hydrolysis of acylated 1-hydroxybenzotriazole (HOW) by McCarthy et al.\* prompted us to describe on our results on the hydrolysis of acetyl HOBt as our conclusions are very different. Our preceding paper reported that HOBt esters of various N-protected amino acids exist