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Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis

✍ Scribed by Yushan Zhu; Lixia Zhao; Lei Liu; Ping Gao; Weili Tian; Xiaohui Wang; Haijing Jin; Haidong Xu; Quan Chen

Book ID
107691973
Publisher
SP Higher Education Press
Year
2010
Tongue
English
Weight
892 KB
Volume
1
Category
Article
ISSN
1674-800X

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The oncogene Akt/PKB/RAC-PK is a serine/threonine kinase that mediates survival signals and has protective effects against apoptosis induced by a variety of stimuli. The kinase activity of Akt has been demonstrated to be critical in transmitting survival signals. We found that Akt protein was down-r