2,3-butanedione 2-monoxime (BDM) inhibits muscle contraction and actomyosin ATPase both in fibres and in solution. It is potentially useful as a tool for exploring weak interactions between actin and myosin. We have examined the effect of BDM on several key steps of the myosin subfragment-1 and acto
โฆ LIBER โฆ
BDM (2,3-butanedione monoxime), an inhibitor of myosin-actin interaction, suppresses myofibrillogenesis in skeletal muscle cells in culture
โ Scribed by Y. Soeno; Y. Shimada; T. Obinata
- Book ID
- 106140502
- Publisher
- Springer-Verlag
- Year
- 1999
- Tongue
- English
- Weight
- 734 KB
- Volume
- 295
- Category
- Article
- ISSN
- 0302-766X
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## Abstract We investigated the role of myosin in polymorphonuclear leucocyte (PMN) shape changes, locomotion, and fluid pinocytosis using the myosin inhibitor 2,3 butanedione monoxime (BDM). Treatment of resting spherical PMNs with BDM produced spheroid cells showing small continuous shape changes