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Bcl2-negative MCF7 cells overexpress p53: implications for the cell cycle and sensitivity to cytotoxic drugs

โœ Scribed by Laura Poliseno; Laura Mariani; Paola Collecchi; Antonio Piras; Lucia Zaccaro; Giuseppe Rainaldi

Book ID
105991647
Publisher
Springer
Year
2002
Tongue
English
Weight
86 KB
Volume
50
Category
Article
ISSN
0344-5704

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Derivatives of camptothecins, topoisomerase I inhibitors and 7-hydroxystaurosporine (UCN-01), a protein kinase C (PKC) inhibitor and cell cycle checkpoint abrogator, are promising anticancer drugs. We characterized the apoptotic response to camptothecin and UCN-01 for the 8 human breast carcinoma ce