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BCL2 in breast cancer: a favourable prognostic marker across molecular subtypes and independent of adjuvant therapy received

✍ Scribed by Dawson, S-J; Makretsov, N; Blows, F M; Driver, K E; Provenzano, E; Le Quesne, J; Baglietto, L; Severi, G; Giles, G G; McLean, C A

Book ID: 110000702
Publisher: Nature Publishing Group
Year: 2010
Tongue: English
Weight: 62 KB
Volume: 103
Category: Article
ISSN: 0007-0920
DOI: 10.1038/sj.bjc.6605921

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Immunocytochemical localization of BCL-2

Immunocytochemical localization of BCL-2 protein in human breast cancers and its relationship to a series of prognostic markers and response to endocrine therapy

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The protein product of the bcl-2 gene is thought to be involved in inhibition of apoptosis; it may therefore be important in the modulation of hormonal/anti-hormonal responsiveness exhibited by tumours. This study immunocytochemically investigates (i) relationships between bcl-2 protein expression i