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Bcl-XL Inhibits Membrane Permeabilization by Competing with Bax

โœ Scribed by Billen, Lieven P.; Kokoski, Candis L.; Lovell, Jonathan F.; Leber, Brian; Andrews, David W.; Walter, Peter


Book ID
120373541
Publisher
Public Library of Science
Year
2008
Tongue
English
Weight
714 KB
Volume
6
Category
Article
ISSN
1544-9173

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We have reported that antisense Bcl-2 oligodeoxynucleotide (ODN) delays progression to androgen independence in the androgen-dependent (AD) mouse Shionogi tumor model. Here, we characterize changes in bcl-xL, another important anti-apoptotic gene, and test the efficacy of adjuvant antisense Bcl-xL O