## Abstract Diffuse large Bโcell lymphoma (DLBCL) is a biologically heterogeneous disease for which the current approach to treatment is only successful for 50% of patients. The prognostic value of various clinical and biological factors in predicting treatment outcome is discussed in this paper. A
Bcl-6, a Prognostic Biomarker in Diffuse Large B-Cell Lymphoma
โ Scribed by Shivakumar, Latha; Jain, Vinay K.
- Book ID
- 118629188
- Publisher
- CIG Media Group, LP.
- Year
- 2006
- Tongue
- English
- Weight
- 120 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1557-9190
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BCL2 is deregulated in diffuse large B-cell lymphoma (DLBCL) by the t(14;18) translocation, gene amplification and/or nuclear factor-kB signaling. RNA-seq data have recently shown that BCL2 is the most highly mutated gene in germinal center B-cell (GCB) DLBCL. We have sequenced BCL2 in 298 primary D
Prognosis of DLCL patients is variable and associated with well-deยฎned risk factors. In the past decade several pretreatment variables have been incorporated into prognostic models to predict the death risk of individual patients. The International Prognostic Index (IPI), developed in an internation