bcl-2 oncoprotein in surgically resected nonsmall cell lung cancer: Possibly favorable prognostic factor in association with low incidence of distant metastasis
✍ Scribed by Higashiyama, Masahiko; Doi, Osamu; Kodama, Ken; Yokouchi, Hideoki; Nakamori, Shoji; Tateishi, Ryuhei
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 254 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0022-4790
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✦ Synopsis
Background:
The bcl-2 oncoprotein serves a regulatory function in permitting several cell types to die in an apoptotic process. its overexpression probably plays a role in tumorigenesis and tumor development. the aim of this study was to determine the clinicopathological and prognostic significance of the bcl-2 oncoprotein in patients with nonsmall cell lung cancer (nsclc).
Methods:
Immunostaining for bcl-2 oncoprotein was performed on 182 operable nsclcs.
Results:
Thirty-six patients (19.8%) showed a positive immunostaining for bcl-2 oncoprotein. histologically, its incidence was higher in squamous cell carcinomas (29.6%). its expression status was inversely correlated with tumor development-associated parameters such as tumor stage in nsclcs, especially in squamous cell carcinomas, bcl-2 positive patients with nsclcs, especially squamous cell carcinomas, showed better overall survival and disease-free survival (dfs). in a multivariate analysis, this oncoprotein status had prognostic value in dfs for nsclcs and in overall survival for squamous cell carcinomas. the recurrence of bcl-2 positive nsclcs was significantly uncommon in distant extrathoracic organs.
Conclusions:
The expression of bcl-2 oncoprotein in nsclcs may be an early event of tumor development, especially in squamous cell carcinomas, and may be of importance in determining tumor progression and prognosis.