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BCL-2 gene family and the regulation of programmed cell death

✍ Scribed by Stanley J. Korsmeyer; Xiao-Ming Yin; Elizabeth Yang; Jiping Zha; Thomas Sedlak; Zoltàn Oltvai

Book ID: 113253835
Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 173 KB
Volume: 84
Category: Article
ISSN: 0165-4608
DOI: 10.1016/0165-4608(96)85244-7

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## Abstract An increase in the permeability of the outer mitochondrial membrane is central to apoptotic cell death, since it leads to the release of several apoptogenic factors, such as cytochrome c and Smac/Diablo, into the cytoplasm that activate downstream death programs. During apoptosis, the m