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BCL-2 family regulation by the 20S proteasome inhibitor bortezomib

โœ Scribed by Fennell, D A; Chacko, A; Mutti, L


Book ID
110072733
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
254 KB
Volume
27
Category
Article
ISSN
0950-9232

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## Abstract An increase in the permeability of the outer mitochondrial membrane is central to apoptotic cell death, since it leads to the release of several apoptogenic factors, such as cytochrome c and Smac/Diablo, into the cytoplasm that activate downstream death programs. During apoptosis, the m