Bcl-2 expression indicates better prognosis of Merkel cell carcinoma regardless of the presence of Merkel cell polyomavirus
✍ Scribed by Sahi, Helka; Koljonen, Virve; Kavola, Heli; Haglund, Caj; Tukiainen, Erkki; Sihto, Harri; Böhling, Tom
- Book ID
- 118785198
- Publisher
- Springer
- Year
- 2012
- Tongue
- English
- Weight
- 415 KB
- Volume
- 461
- Category
- Article
- ISSN
- 1432-2307
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## Abstract The recently discovered human polyomavirus (MCPyV) is frequently found in Merkel cell carcinoma (MCC) tissue and is believed to be causally linked to MCC pathogenesis. While cell lines established from MCC represent a valuable tool to study the contribution of MCPyV to MCC pathogenesis,
Since their first description in 1875, Merkel cells have remained an elusive cell type. Their origin as well as their classification as mechanoreceptors have been a matter of controversy and intense discussion. The peptidergic granules in these cells are suggestive of neuroendocrine functions, but t
Since their first description in 1875, Merkel cells have remained an elusive cell type. Their origin as well as their classification as mechanoreceptors have been a matter of controversy and intense discussion. The peptidergic granules in these cells are suggestive of neuroendocrine functions, but t