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bcl-2 expression in synovial sarcoma

✍ Scribed by Pilotti, Silvana; Mezzelani, Alessandra; Azzarelli, Alberto; Rilke, Franco; Pierotti, Marco A.

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 80 KB
Volume: 184
Category: Article
ISSN: 0022-3417
DOI: 10.1002/(sici)1096-9896(199803)184:3<337::aid-path22>3.0.co;2-j

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✦ Synopsis

LETTERS TO THE EDITOR bcl-2 EXPRESSION IN SYNOVIAL SARCOMA Chilosi et al., in their contribution entitled 'bcl-2 expression in pleural and extrapleural solitary fibrous tumours', recently published in the journal, 1 pointed out that among CD34-negative extrapleural mesenchymal tumours, a strong bcl-2 immunoreactivity, comparable to that shown by solitary fibrous tumours, was observed in four cases of synovial sarcoma.

Here we confirm this observation in a larger series of synovial sarcoma. bcl-2 overexpression was the only immunoreactivity consistently observed in 56 samples from 35 cases [five of which were confirmed by reverse transcription-polymerase chain reaction (RT-PCR) analysis] examined by a panel of antibodies directed against bcl-2 (diluted 1:20, a gift from Dr Mason), p53 (diluted 1:100, Novocastra), mdm2 (diluted 1:200, Ylem), p21/waf1 (diluted 1:400, Santa Cruz) and cdk4 gene products (diluted 1:400, Santa Cruz), in addition to CD34 (diluted 1:500, Novocastra). Immunocyto-

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