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BCL-2 antisense (G3139) plus docetaxel for treatment of progressive androgen-independent prostate cancer

โœ Scribed by M.J. Morris; W.P. Tong; C. Cordon-Cardo; M. Drobnjak; W.K. Kelly; S.F. Slovin; N. Rosen; H.I. Scher


Book ID
117658656
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
358 KB
Volume
37
Category
Article
ISSN
0959-8049

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Inhibition of progression to androgen-in
โœ Hideaki Miyake; Brett P. Monia; Martin E. Gleave ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 184 KB ๐Ÿ‘ 2 views

We have reported that antisense Bcl-2 oligodeoxynucleotide (ODN) delays progression to androgen independence in the androgen-dependent (AD) mouse Shionogi tumor model. Here, we characterize changes in bcl-xL, another important anti-apoptotic gene, and test the efficacy of adjuvant antisense Bcl-xL O