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BCAN Think Tank session 1: Overview of risks for and causes of bladder cancer

✍ Scribed by Alexandre R. Zlotta; Samuel M. Cohen; Colin Dinney; Michael Droller; Theo H. van der Kwast; Bas W.G. van Rhijn; Bernard Bochner; Gilad Ameil; Michael A.S. Jewett

Book ID
116956667
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
149 KB
Volume
28
Category
Article
ISSN
1078-1439

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## Abstract Apurinic/apyrimidinic (AP) sites are common mutagenic and cytotoxic DNA lesions that arise from the loss of normal bases. APE1, the major AP endonuclease of human cells, plays a central role in the repair of AP sites through both its endonuclease and phosphodiesterase activities. A comm