We introduce a population model to design optimal apheresis schedules to collect blood stem cells from cancer patients. Blood stem cells are collected prior to the patient undergoing high-dose chemoradiotherapy and are returned after this treatment to enable reconstitution of the white blood cell co
Bayesian optimal design for changepoint problems
β Scribed by Juli Atherton; Benoit Charbonneau; David B. Wolfson; Lawrence Joseph; Xiaojie Zhou; Alain C. Vandal
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- French
- Weight
- 191 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0319-5724
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
We investigate Bayesian optimal designs for changepoint problems. We find robust optimal designs which allow for arbitrary distributions before and after the change, arbitrary prior densities on the parameters before and after the change, and any logβconcave prior density on the changepoint. We define a new design measure for Bayesian optimal design problems as a means of finding the optimal design. Our results apply to any design criterion function concave in the design measure. We illustrate our results by finding the optimal design in a problem motivated by a previous clinical trial. The Canadian Journal of Statistics 37: 495β513; 2009 Β© 2009 Statistical Society of Canada
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