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Bayesian Modeling for Genetic Anticipation in Presence of Mutational Heterogeneity: A Case Study in Lynch Syndrome

✍ Scribed by Philip S. Boonstra; Bhramar Mukherjee; Jeremy M. G. Taylor; Mef Nilbert; Victor Moreno; Stephen B. Gruber


Book ID
109224538
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
388 KB
Volume
67
Category
Article
ISSN
0006-341X

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## Abstract Anticipation, manifested through decreasing age of onset or increased severity in successive generations, has been noted in several genetic diseases. Statistical methods for genetic anticipation range from a simple use of the paired __t__‐test for age of onset restricted to affected par