Bayesian interim analysis of phase II ca
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Daniel F. Heitjan
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Article
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1997
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John Wiley and Sons
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English
โ 111 KB
๐ 2 views
Many popular sequential phase II clinical trial designs optimize some criterion subject to constraints on the error probabilities at null and alternative values of the response rate. Such designs may forfeit optimality if one fails to conduct analyses strictly according to plan. Moreover, a decision