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Bayesian Fine-Scale Mapping of Disease Loci, by Hidden Markov Models

✍ Scribed by A.P. Morris; J.C. Whittaker; D.J. Balding

Book ID
117853327
Publisher
American Society of Human Genetics
Year
2000
Tongue
English
Weight
780 KB
Volume
67
Category
Article
ISSN
0002-9297

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## Abstract We present a novel statistical method for linkage disequilibrium (LD) mapping of disease susceptibility loci in case‐control studies. Such studies exploit the statistical correlation or LD that exist between variants physically close along the genome to identify those that correlate wit