BAYESIAN DOSIMETRY II: CREDIBILITY INTERVALS FOR RADIATION DOSE

✍ Scribed by MARIA REGINA MADRUGA; TANIA HELENA OCHI-LOHMANN; KAYO OKAZAKI; CARLOS ALBERTO DE BRAGANÇA PEREIRA; MARIA NAZARETH RABELLO-GAY

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 346 KB
• Volume: 7
• Category: Article
• ISSN: 1180-4009
• DOI: 10.1002/(sici)1099-095x(199605)7:3<325::aid-env216>3.0.co;2-y

✦ Synopsis

This paper is the natural sequel to Madruga ef al. (Environmetrics, 547-56 (1994)) where data from literature were analysed. Here, three sets of experimental data were obtained at IPEN (Energetic and Nuclear Research Institute) from blood cultures from three patients with basal cellular carcinoma (1 male, age 68, and 2 females, ages 47 and 66), four healthy young subjects (2 males, ages 24 and 27, and 2 females, ages 20 and 27) and two older healthy subjects (1 male, age 50, and 1 female, age 46). These cultures were exposed in vitro to ' %o radiati0.n ranging from 0 to 500cGy. The frequencies of cells with one or two nuclei, with or without micronuclei (MN), are the responses. Models for mono-and binucleated cells were obtained. As suggested in Madruga et al., models for mononucleated are simpler than for binucleated cells. The novelty is that, based on the observed frequencies of micronucleated cells, we can generate credible intervals for unknown doses to which an individual was exposed.