Bayesian designs for phase I-II clinical trials

✍ Scribed by Nguyen, Hoang Q.; Thall, Peter F.; Yuan, Ying

Publisher: Taylor & Francis, CRC
Year: 2016
Tongue: English
Leaves: 316
Series: Chapman & Hall/CRC biostatistics series
Category: Library

No coin nor oath required. For personal study only.

✦ Table of Contents

Content: 1. Why conduct phase I-II trials? --
2. The phase I-II paradigm --
3. Establishing priors --
4. Efficacy : toxicity trade-off-based designs --
5. Designs with late-onset outcomes --
6. Utility-based designs --
7. Personalized dose finding --
8. Combination trials --
9. Optimizing molecularly targeted agents --
10. Optimizing doses in two cycles --
11. Optimizing dose and schedule --
12. Dealing with dropouts --
13. Optimizing intra-arterial tPA --
14. Optimizing sedative dose in preterm infants.

✦ Subjects

Clinical trials;Statistical methods.;Drugs;Testing;Statistical methods.;Bayesian statistical decision theory.;MEDICAL / Pharmacology

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