Bay K 8644 induce enhancement of K+current in both single heart cell and smooth muscle cell

✍ Scribed by J -F Renaud; G. Bkaily; M. Benabderrazik; D. Jacques; N. Sperelakis

• Publisher: Springer
• Year: 1989
• Tongue: English
• Weight: 353 KB
• Volume: 80
• Category: Article
• ISSN: 0300-8177
• DOI: 10.1007/bf00231005

✦ Synopsis

The effects of the Ca2+ agonist Bay K 8644 on outward potassium currents have been studied in single ventricular cells of chick embryo and aortic single cells of rabbit using the whole-cell patch clamp technique. Bay K 8644 was found to increase 1K in both heart and aortic single cells. This effect of Bay K 8644 on both muscle was reversed by Mn2+ and blocked by 20 mM TEA. The Bay K 8644 potassium I/V curve of single heart cell had a N shape, which is Ca2+ dependent. These data strongly suggest that Bay K 8644 increases a gK(Ca) in both aortic and heart muscle.