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Bax translocation is crucial for the sensitivity of leukaemic cells to etoposide-induced apoptosis

โœ Scribed by Jia, Li; Patwari, Yasmeen; Srinivasula, Srinivasa M; Newland, Adrian C; Fernandes-Alnemri, Teresa; Alnemri, Emad S; Kelsey, Stephen M


Book ID
110065883
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
416 KB
Volume
20
Category
Article
ISSN
0950-9232

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Resistance to apoptosis plays an important role in malignancies that are refractory to chemotherapy treatment. Recently we have shown that the expression of bax-a, a death-promoting member of the bcl-2 family, is down-regulated in breast cancer and have provided evidence that low bax expression migh