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BAX protein is not expressed by basal cell carcinomas

✍ Scribed by Rossen; Karabulut Thorup; Hou-Jensen; Krag Jacobsen

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 299 KB
Volume: 139
Category: Article
ISSN: 0007-0963
DOI: 10.1046/j.1365-2133.1998.02412.x

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✦ Synopsis

BAX and related proteins encoded by the BCL2 gene family are involved in the regulation of apoptosis. BAX is an apoptosis-promoting protein. The slow growth of basal cell carcinoma (BCC) has so far been explained by a high apoptotic activity. We investigated immunohistochemically 27 BCCs for expression of the apoptosis-promoting BAX protein. BCC did not express detectable amounts of BAX immunohistochemically. The results indicate that apoptosis in BCC does not involve BAX protein. We propose that the apoptotic pathway in BCC is regulated by either less common members of the BCL2 gene family or bypasses the regulation of the BCL2 gene family.

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