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Bax, a predictive marker for therapeutic response to preoperative chemoradiotherapy in patients with rectal carcinoma

✍ Scribed by Hee Jin Chang; Kyung Hae Jung; Dae Yong Kim; Seung-Yong Jeong; Hyo Seong Choi; Young Hoon Kim; Dae Kyung Sohn; Byong Chul Yoo; Seok-Byung Lim; Dae-Hyun Kim; Joong-Bae Ahn; Il-Jin Kim; Jin Man Kim; Wan-Hee Yoon; Jae-Gahb Park

Book ID
116533901
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
403 KB
Volume
36
Category
Article
ISSN
1532-8392

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Bax, a predictive marker for therapeutic
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In an attempt to improve local control and survival in patients with advanced rectal carcinoma, neoadjuvant chemoradiation therapy (CRT) has been increasingly used in patient management. However, a significant proportion of patients shows poor response to adjuvant CRT. Thus, the ability to predict C

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## Abstract ## Purpose To identify if thymidine phosphorylase (TP), dihydropyrimidine dehydrogenase (DPD), and ratio TP/DPD levels in tumor tissues are potential predictive factors for response to combined preoperative chemoradiation with capecitabine, in patients with locally advanced rectal canc

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## Abstract ## BACKGROUND Although controversial, some believe that preoperative chemoradiation increases the use of sphincter‐preserving surgery in low rectal carcinoma patients. This article investigates the relationship between objective tumor response and sphincter preservation in low rectal c