Bausteine von Oligosacchariden, CVI. Darstellung synthetischer Antigene vonLD-Heptose-haltigen Trisacchariden der Core-Region von Lipopolysacchariden durch Copolymerisation mit Acrylamid
✍ Scribed by Paulsen, Hans ;Höffgen, Elisabeth C.
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 908 KB
- Volume
- 1993
- Category
- Article
- ISSN
- 0947-3440
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✦ Synopsis
Building Units of Oligosaccharides, CVI. – Preparation of Synthetic Antigens Composed of LD‐Heptose‐Containing Trisaccharides of the Core Region of Lipopolysaccharides by Copolymerization with Acrylamide
The allyl glycosides of the trisaccharide L‐α‐D‐Hep‐(1→3)‐α‐D‐Hep‐(1→5)‐Kdo in the α form 3 and β form 6 and furthermore of L‐α‐D‐Hep‐(1→7)‐L‐α‐D‐Hep‐(1→3)‐L‐α‐D‐Hep in the α form 20 were synthesized. The allyl glycosides were coupled with a cysteamin spacer in a radical‐addition reaction followed by an acylation with acryloyl chloride. The products could be copolymerized with acrylamide to afford the polymers 21, 22 and 23 with the trisaccharide structure as an immunological determinant.