Bausteine von Oligosacchariden, CI. Synthese von modifizierten Oligosacchariden derN-Glycoproteine zur Untersuchung der Substratspezifität derN-Acetylglucosaminyltransferase II des Trimming-Prozesses
✍ Scribed by Paulsen, Hans ;van Dorst, Johannes A. L. M. ;Reck, Folkert ;Meinjohanns, Ernst
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 979 KB
- Volume
- 1992
- Category
- Article
- ISSN
- 0947-3440
No coin nor oath required. For personal study only.
✦ Synopsis
Building Units of Oligosaccharides, CI. — Synthesis of Modified Oligosaccharides of the N‐Glycoproteins Intended for Substrate Specificity Studies of N‐Acetylglucosaminyltransferase II of the Trimming Process
The trichloroacetimidate method was very successful for the synthesis of the tetrasaccharide octyl O‐(2‐acetamido‐2‐deoxy‐β‐D‐glucopyranosyl)‐(1→2)‐O‐(α‐D‐mannopyranosyl)‐(1→3)‐O‐[(α‐D‐mannopyranosyl)‐(1→6)]‐β‐D‐mannopyranoside (10). Further derivatives of the tetrasaccharide with a 4‐O‐methyl group 20 and with a 4‐deoxy group 28 were synthesized. The tetrasaccharides are intended for substrate specificity studies of the N‐acetylglucosaminyltransferase II of the trimming process in the biosynthesis of N‐glycoproteins.