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Bauhinoxepins A and B: New Antimycobacterial Dibenzo[b,f]oxepins from Bauhinia saccocalyx

✍ Scribed by Prasat Kittakoop; Sombat Nopichai; Nuntawan Thongon; Panarat Charoenchai; Yodhathai Thebtaranonth

Publisher
John Wiley and Sons
Year
2004
Tongue
German
Weight
67 KB
Volume
87
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Two new antimycobacterial dibenzo[b,f]oxepins, bauhinoxepins A (=3,3,5‐trimethylbenzo[b]pyrano[g][1]benzoxepin‐6,11‐diol; 1) and B (=6‐methoxy‐7‐methyl‐2‐(3‐methylbut‐2‐enyl)dibenzo[b,f]oxepine‐1,8‐diol; 2), were isolated from the roots of Bauhinia saccocalyx, and their structures were elucidated by analysis of spectroscopic data. Bauhinoxepins A and B exhibited antimycobacterial activities with respective minimum‐inhibitory concentrations (MIC) of 6.25 and 12.5 μg/ml. They were inactive (at 20 μg/ml) against the malarial parasite, and also inactive (at 20 μg/ml) towards the Vero, KB, and BC cell lines.

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