✦ LIBER ✦

Basicities of thiazole heterocyclic compounds and the reaction of 3-methyl-2-methylimino-Δ4-thiazolines with ethyl bromoacetate and 2-bromoacetophenone

✍ Scribed by Dong Chan Kim; Kyung Ho Yoo; Kye Jung Shin; Sang Woo Park; Dong Jin Kim

Book ID: 102892162
Publisher: Journal of Heterocyclic Chemistry
Year: 1997
Tongue: English
Weight: 537 KB
Volume: 34
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570340110

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The p__K__~a~′s of several thiazole heterocyclic compounds have been determined and represent products with significantly high values. Because of their high basicities, sometimes these compounds were able to act as not only nucleophiles but also strong organic bases. 4‐Substituted‐3‐methyl‐2‐methylimino‐Δ^4^‐thiazolines 5a‐d reacted with ethyl bromoacetate in refluxing benzene, giving the corresponding N‐alkylated salts 8a‐d, while the products obtained from the reaction with 2‐bromoacetophenone in the presence of base were pyrrolothiazines 10b‐d.

📜 SIMILAR VOLUMES

ChemInform Abstract: Basicities of Thiaz

ChemInform Abstract: Basicities of Thiazole Heterocyclic Compounds and the Reaction of 3- Methyl-2-methylimino-δ4-thiazolines with Ethyl Bromoacetate and 2-Bromoacetophenone.

✍ D. C. KIM; K. H. YOO; K. J. SHIN; S. W. PARK; D. J. KIM 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 1 views

ChemInform Abstract: Reactions of Second

ChemInform Abstract: Reactions of Secondary β-Ketothioamides with Ethyl Bromoacetate and Ethyl 2-Bromopropionate. The Synthesis of N-Substituted 2-Acylmethylidene-1,3-thiazolidin-4-ones.

✍ T. S. Jagodzinski; A. Wesolowska; J. G. Sosnicki 📂 Article 📅 2000 🏛 John Wiley and Sons ⚖ 36 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

A Simple Synthesis of 2′,5′-Disubstitute

A Simple Synthesis of 2′,5′-Disubstituted-Spiro [Dihydroacridine 9(10H), 4′-Thiazolines] by the Reaction of Corresponding 3-(Acridin-9-Yl)-Thioureas with Methyl Bromoacetate and Bromoacetonitrile

✍ Bernát, Juraj; Chomča, Igor; Kristian, Pavol; Voss, Gundula 📂 Article 📅 1998 🏛 Taylor and Francis Group 🌐 English ⚖ 315 KB

Heterocyclic thiones and their analogs i

Heterocyclic thiones and their analogs in 1,3-dipolar cycloaddition: VII. Reaction of 4-methyl-1,3-thiazole-2(3H)-thiones with nitrile imines

✍ E. V. Budarina; T. S. Dolgushina; M. L. Petrov; N. N. Labeish; A. A. Kol’tsov; V 📂 Article 📅 2007 🏛 SP MAIK Nauka/Interperiodica 🌐 English ⚖ 235 KB

ChemInform Abstract: A Simple Synthesis

ChemInform Abstract: A Simple Synthesis of 2′,5′-Disubstituted-Spiro[dihydroacridine 9(10H), 4′-Thiazolines] by the Reaction of Corresponding 3-(Acridin-9-yl)-thioureas with Methyl Bromoacetate and Bromoacetonitrile.

✍ J. BERNAT; I. CHOMCA; P. KRISTIAN; G. VOSS 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 1 views

Nitriles in heterocyclic synthesis: The

Nitriles in heterocyclic synthesis: The reaction of ethyl 2-oxoindoliden-3-ylidene cyanoacetate and of 3-dicyanoethylideneindoliden-2-one with phenols and amines

✍ Kamal Usef Sadek; Maghraby Ali Selim; Mohamed Ali; Mohamed Hilmy Elnagdi 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 320 KB

The reactions of ethyl 2-oxoindoliden-3-ylidene cyanoacetate (2a) and of 3-dicyanoethylideneindoliden-2-one (2b) with phenols and amines have been reported. 0 1996 John Wiley & Sons, Inc. a$-Unsaturated nitriles are highly reactive reagents and have been extensively utilized in heterocyclic synthesi