𝔖 Bobbio Scriptorium

✦ LIBER ✦

Basic science/optical diagnostics

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 150 KB
Volume: 39
Category: Article
ISSN: 0196-8092
DOI: 10.1002/lsm.20495

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✦ Synopsis

Since blood flow is tightly coupled to the health status of biological tissue, several instruments have been developed to monitor blood flow and perfusion dynamics. One such instrument is laser speckle imaging (LSI), which involves analysis of the spatial statistics of time-integrated speckle (i.e, speckle contrast). We introduce a novel contrast mechanism for imaging blood vessels using magneto-motive LSI. This method combines an externally applied temporally oscillating high-strength magnetic field with LSI. The magnetic field causes exogenous superparamagnetic iron oxide (SPIO) nanoparticles (average diameter ~100 nm) to oscillate in the blood and act as a contrast agent for LSI. Application of the technique is demonstrated using an in vitro blood flow phantom. Our data suggest that MM-LSI may be a promising technique to enhance hemoglobin and SPIO nanoparticle contrast for imaging blood vessels.

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