𝔖 Bobbio Scriptorium
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Basic science reviews. Immunology of head and neck cancer: Perspectives

✍ Scribed by Norris K. Lee; Giorgio Cortesina; Manuela Sacchi; Emanuela Galeazzi; Antonella De Stefani

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
417 KB
Volume
15
Category
Article
ISSN
1043-3074

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✦ Synopsis

Patients with head and neck cancer have immune impairment, demonstrable at several levels, often related t o the clinical tumor stage. Researchers have focused on this unique system to understand locoregional cancer biology and to develop new therapeutic strategies. Along with classic cellular immunology, which has already resulted in several new theories and therapies, recent molecular biologic data are providing stimulating insights into cancer immunology and the larger field of tumor-host interactions.

CELLULAR IMMUNOLOGY

Deficits of Cellular Function in the Head and Neck

Tumor Model. Host immune response against a tumor is heterogeneous. The various immune mechanisms involved include effector cells, their target structures, and regulatory elements. With appropriate orchestration, two main mechanisms of antitumor control normally exist: the natural killer (NK) nonspecific response and the specific response that is dependent on antigen presentation by the molecules of the major histocompatibility complex (MHC).

In head and neck cancer, deficits of the NK

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