Basic pharmacophore of some antithrombotic agents with combined thromboxane receptor antagonist (TxRA)/thromboxane synthase inhibitor (TxSI) activity

✍ Scribed by Yang Jie; Hua Weiyi

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 298 KB
• Volume: 39
• Category: Article
• ISSN: 0272-4391
• DOI: 10.1002/(sici)1098-2299(199610)39:2<197::aid-ddr14>3.0.co;2-9

✦ Synopsis

Platelet activation, causing formation of platelet aggregates, plays a major role in occlusive thrombus formation which may induce ischemic cardiovascular diseases. Thromboxane A2 (TXA2) is an extremely potent vasoconstricting and platelet-aggregating agent so that it is important to search for a new type of thromboxane synthase inhibitor combined with thromboxane receptor antagonism ( T x W x S I ) dual blocker with high potency and less side effects. On the basis of the structures of some known T x W x S I dual blockers, we used 3D molecular modelling to search for pharmacophores for the dual blockers.