## Abstract Over the last two decades, since the initial discovery of human papillomavirus (HPV) type 16 and 18 DNAs in cervical cancers by Dr. Harald zur Hausen (winner of the Nobel Prize in Physiology or Medicine, 2008), the HPVs have been well characterised as causative agents for cervical cance
Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: Roles of E6 and E7 proteins
โ Scribed by Mako Narisawa-Saito; Tohru Kiyono
- Book ID
- 108583955
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 367 KB
- Volume
- 98
- Category
- Article
- ISSN
- 1347-9032
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Human papillomavirus (HPV) DNA sequences are found in most carcinomas originating from the uterine cervix. HPV E6 and E7 oncogenes have been shown to cooperate with ras oncogenes to fully transform human epithelial cells. We investigated the effect of the Ha-ras oncogene on the transcriptional activ
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