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Basic fibroblast growth factor prevents cAMP-induced apoptosis in cultured Schwann cells

โœ Scribed by R. Shaw; R. Cianchetti; D. Pleasure; B. Kreider

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
97 KB
Volume
47
Category
Article
ISSN
0360-4012

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โœฆ Synopsis

In this study, we investigate the effects of bFGF on apoptosis in neuron-free cultures of neonatal rat Schwann cells. Apoptotic cell death was induced in primary and secondary expanded Schwann cells by treatment with 1 mM concentrations of 8-bromoadenosine 38:58-cyclic monophosphate (8-bromo-cAMP), a membrane-permeable analogue of cAMP which induces expression of galactocerebroside in the plasma membranes of Schwann cells. Treatment with bFGF reduced the percentage of galactocerebroside-bearing Schwann cells undergoing cAMP-induced DNA fragmentation. These findings suggest that bFGF can enhance the survival of terminally differentiated Schwann cells by preventing apoptosis.

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