Basic cholane derivatives. XI: Comparison between acid and basic derivatives
โ Scribed by Adamo Fini; Giuseppe Fazio; Aldo Roda; Anna Maria Bellini; Elena Mencini; Mario Guarneri
- Book ID
- 102916524
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 588 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0022-3549
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Twenty new compounds derived from deoxycholic acid have been synthesi-Antlmlkrobiell wlrksame besisehe Cholanderivate zed They contain two basic functions: at C-24 (bemylamino, morpholino, diethanolamino, N,N-diethylethylenediamino, N-methylpipemzino) and at B-C-3 (amino, methylamino, ethylamino, be
A representative series of hydroxy-5 beta-cholanyl-24-amines were tested both in vitro and in vivo with respect to their activity against the intestinal bacteria responsible for bile acid metabolism. For the in vitro studies, radiolabeled [14C]cholic acid was incubated with human stools both in aero