✦ LIBER ✦

Basic and clinical research on photodynamic therapy at Tokyo Medical University Hospital

✍ Scribed by H. Kato; J. Usuda; T. Okunaka; K. Furukawa; H. Honda; N. Sakaniwa; Y. Suga; T. Hirata; K. Ohtani; T. Inoue; S. Maehara; M. Kubota; K. Yamada; H. Tsuitsui

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 92 KB
Volume: 38
Category: Article
ISSN: 0196-8092
DOI: 10.1002/lsm.20346

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background and Objectives

We have been engaged in basic and clinical research on photodynamic therapy (PDT) and photodynamic diagnosis (PDD) for more than 25 years.

Study Design/Materials and Methods

PDT for 264 centrally located early‐stage lung cancer lesions yielded an initial complete response (CR) rate of 84.8%. PDT is now becoming a standard option for centrally located stage 0 (TisN0M0) and stage I (T1N0M0) lung cancer. It is an attractive option for elderly patients in poor physical condition.

Results

Recent results of interstitial PDT for peripheral‐type lung cancers suggest that it may be a promising local curative treatment modality for lesions less than 1.0 cm in diameter.

Conclusions

In this article, we introduce our recent clinical trials of PDT for lung cancers (both central and peripheral), and new techniques of PDD in sentinel node navigation biopsy for breast cancers. Moreover, we introduce basic research on cancers and infectious diseases in order to expand the clinical applications of PDT. Lasers Surg. Med. 38:371–375, 2006. © 2006 Wiley‐Liss, Inc.

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