Base-solvent systems for inducing clean bimolecular 1,2-eliminations

Direct proof for the occurrence of anion

Direct proof for the occurrence of anions in the base-induced 1,4-elimination of alcohol from 1,4-dialkoxy-2-butynes

✍ P. E. van Rijn; R. H. Everhardus; L. Brandsma 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 133 KB

## Abstract 1,4‐Elimination of alcohols from ether of the type RO‐CH~2~ ‐C≡C‐CH~2~‐OR by treating these compounds with alkali amide, appears to be not a concerted process, but to proceed via short‐lived anions. These anions can be intercepted by ethyl bromide, present during the reaction.