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Base pairs and pseudo pairs observed in RNA–ligand complexes

✍ Scribed by Jiro Kondo; Eric Westhof

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
612 KB
Volume
23
Category
Article
ISSN
0952-3499

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✦ Synopsis

Abstract

Previously, a geometric nomenclature was proposed in which RNA base pairs were classified by their interaction edges (Watson–Crick, Hoogsteen or sugar‐edge) and the glycosidic bond orientations relative to the hydrogen bonds formed (cis or trans). Here, base pairs and pseudo pairs observed in RNA–ligand complexes are classified in a similar manner. Twenty‐one basic geometric families are geometrically possible (18 for base pairs formed between a nucleic acid base and a ligand containing heterocycle and 3 families for pseudo pairs). Of those, 16 of them have been observed in X‐ray and/or NMR structures. Copyright © 2009 John Wiley & Sons, Ltd.

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