Base-catalyzed intramolecular heterocyclization of o-alkynylbenzhydrazides
β Scribed by T. F. Mikhailovskaya; S. F. Vasilevsky
- Book ID
- 106521581
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 270 KB
- Volume
- 59
- Category
- Article
- ISSN
- 1573-9171
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Treatment of diligustilide (I) with base afforded the pentacyclic compounds 2 -4 with novel carbon-carbon connectivities via lactone-ring opening, intramolecutar condensations and competitive equilibrations. This reaction provides a useful entry to modified dimeric phthalides.
The novel pentacyclic compound cyclotokinolide B was obtained from the natural phthalide tokinolide B under basic conditions, via the chemoselective g-enol lactone opening followed by a Michael addition of the generated carbanion to the enone and subsequent equilibration. This result confirms that s
Catalytic amounts of Pd(OAc)2 in the presence of c-Bu4NC1, OMF and an appropriate Et3N) cyclize nitrogen-containing o-lodoaryl alkenes to indoles, quinolines, isoquinolines and isoquTnolones in short reaction times, under mild temperatures, and in high yields. Transition metal reagents have proven h