Base-catalyzed deuterium and tritium labelling of 1-biphenyl-4-ylpropane-1,2-dione and deuteration of aryl methyl ketones

✍ Scribed by Carl Berthelette; John Scheigetz

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: French
• Weight: 78 KB
• Volume: 47
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.879

✦ Synopsis

Abstract

A synthesis and a base‐catalyzed exchange reaction was developed under mild conditions to deuterate and subsequently tritiate the methyl group of the base sensitive diketone 1‐biphenyl‐4‐ylpropane‐l,2‐dione depicted in Figure 1. Using Et~3~N as base, deuterium incorporation of the methyl group was 88.9% and the tritium incorporation gave a specific radioactivity of 119 mCi/mmol. The scope of the exchanges was extended to methyl aryl ketones 2–4. Copyright © 2004 John Wiley & Sons, Ltd.